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Hitt og þetta 28. júní 2006

Hugin Ad hoc announcement according to § 15 WpHG: Misc. matters: Biofrontera AG: Biofronte

Leverkusen, 28 June 2006 - Biofrontera AG, together with the banks of the underwriting syndicate, have determined the offer price in connection with the public offering in Germany at EUR 15.00 per share. It is expected that the shares will be initially listed on the regulated market (Prime Standard) of the Frankfurt Stock Exchange on 6 July 2006. Delivery of the shares against payment of the offer price is expected to occur on 7 July 2006.

Biofrontera AG, Hemmelrather Weg 201, 51377 Leverkusen ISIN: DE0006046113 WKN: 604611 Admission applied: regulated market of the Frankfurt Stock Exchange (Prime Standard)

Disclaimer: These materials are not for distribution, directly or indirectly, in or into the United States of America. These materials do not constitute or form a part of any offer or solicitation to purchase or subscribe for securities. The shares mentioned herein may not be offered or sold in the United States absent registration or an exemption from registration under the U.S. Securities Act of 1933, as amended (the "Securities Act"). The shares have not been, and will not be, registered under the Securities Act and will not be publicly offered anywhere outside Germany.

Contact: Anke zur Mühlen Biofrontera AG Tel.: +49 (0214) 87 63 222 Fax.: +49 (0214) 87 63 290 e-mail: a.zurmuehlen@biofrontera.com

--- End of Ad-hoc Message --- WKN: 604611; ISIN: DE0006046113; Listed: Geregelter Markt in Frankfurter Wertpapierbörse, Prime Standard in Frankfurter Wertpapierbörse;